Achievements
2025年
- Jena PK, Wakita D, Gomez AC, Carvalho TT, Atici AE, Aubuchon E, Narayanan M, Lee Y, Fishbein MC, Takasato Y, Kurashima Y, Kiyono H, Cani PD, de Vos WM, Underhill DM, Devkota S, Chen S, Shimada K, Crother TR, Arditi M, Noval Rivas M. Intestinal Microbiota Contributes to the Development of Cardiovascular Inflammation and Vasculitis in Mice. Circ Res. 2025 Mar 3. doi: 10.1161/CIRCRESAHA.124.325079. Epub ahead of print. PMID: 40026151.
2024年
- Hattori K, Tanaka S, Hashiba D, Tamura J, Etori K, Kageyama T, Ito T, Meguro K, Iwata A, Suto A, Suzuki K, Nakamura J, Ohtori S, Ziegler SF, Nakajima H. Synovial regulatory T cells expressing ST2 deteriorate joint inflammation through the suppression of immunoregulatory eosinophils. J Autoimmun. 2024 Dec;149:103333. doi: 10.1016/j.jaut.2024.103333. Epub 2024 Nov 6. PMID: 39509740.
- Yahaba M, Asano H, Saito K, Murata S, Kawasaki K, Chiba H, Yokota S, Yoshikawa H, Herai Y, Yamagishi K, Shiko Y, Matsushita K, Hanaoka H, Taniguchi T, Yokote K, Nakajima H, Ido E, Igari H. Antibody Responses and Infection Prevention following the Sixth Vaccination using the BA.1 bivalent COVID-19 vaccine among Healthcare workers during the XBB variant Dominance in Japan. Jpn J Infect Dis. 2024 Nov 29. doi: 10.7883/yoken.JJID.2024.116. Epub ahead of print. PMID: 39617483.
- Suzuki Y, Kawasaki T, Tatsumi K, Okaya T, Sato S, Shimada A, Misawa T, Hatano R, Morimoto C, Kasuya Y, Hasegawa Y, Ohara O, Suzuki T. Transcriptome Analysis of Fibroblasts in Hypoxia-Induced Vascular Remodeling: Functional Roles of CD26/DPP4. Int J Mol Sci. 2024 Nov 23;25(23):12599. doi: 10.3390/ijms252312599. PMID: 39684311; PMCID: PMC11640941.
- Suzuki K, Goto Y, Otomo A, Shimizu K, Abe S, Moriyama K, Yasuda S, Hashimoto Y, Kurushima J, Mikuriya S, Imai FL, Adachi N, Kawasaki M, Sato Y, Ogasawara S, Iwata S, Senda T, Ikeguchi M, Tomita H, Iino R, Moriya T, Murata T. Na+-V-ATPase inhibitor curbs VRE growth and unveils Na+ pathway structure. Nat Struct Mol Biol. 2024 Nov 21. doi: 10.1038/s41594-024-01419-y. Epub ahead of print. PMID: 39572733.
- Yuki Y, Kurokawa S, Sugiura K, Kashima K, Maruyama S, Yamanoue T, Honma A, Mejima M, Takeyama N, Kuroda M, Kozuka-Hata H, Oyama M, Masumura T, Nakahashi-Ouchida R, Fujihashi K, Hiraizumi T, Goto E, Kiyono H. MucoRice-CTB line 19A, a new marker-free transgenic rice-based cholera vaccine produced in an LED-based hydroponic system. Front Plant Sci. 2024 Mar 15;15:1342662. doi: 10.3389/fpls.2024.1342662.
- Tsai J-Y, Fujihashi K. Mucosal vaccine delivery. Advanced Vaccination Technologies for Infectious and Chronic Diseases: A guide to Vaccinolog. Apostolopoulos, V., Vora, L.K., and Chavda, V.P. (Eds). Chapter 12 Elsevier Inc., San Diego CA, USA. 2024. Paperback ISBN: 9780443185649, eBook ISBN: 9780443185656.
- Imai S, Sakao S, Nagata J, Naito A, Sekine A, Sugiura T, Shigeta A, Nishiyama A, Yokota H, Shimizu N, Sugawara T, Nomi T, Honda S, Ogaki K, Tanabe N, Baba T, Suzuki T. Artificial intelligence-based model for predicting pulmonary arterial hypertension on chest x-ray images. BMC Pulm Med. 2024 Feb 27;24(1):101. doi: 10.1186/s12890-024-02891-4.
- Kamii Y, Hayashizaki K, Kanno T, Chiba A, Ikegami T, Saito M, Akeda Y, Ohteki T, Kubo M, Yoshida K, Kawakami K, Oishi K, Araya J, Kuwano K, Kronenberg M, Endo Y, and Kinjo Y. IL-27 regulates the differentiation of follicular helper NKT cells via metabolic adaptation of mitochondria. Proc Natl Acad Sci U.S.A. 2024 Feb 27;121(9):e2313964121, doi:10.1073/pnas.2313964121.
- Tanaka S, Yamamoto T, Iwata A, Kiuchi M, Kokubo K, Iinuma T, Sugiyama T, Hanazawa T, Hirahara K, Ikeda K, Nakajima H. Single-cell RNA sequencing of submandibular gland reveals collagen type XV-positive fibroblasts as a disease-characterizing cell population of IgG4-related disease. Arthritis Res Ther. 2024 Feb 20;26(1):55. doi: 10.1186/s13075-024-03289-7.
- Runtuwene LR, Parbie PK, Mizutani T, Ishizaka A, Matsuoka S, Abana CZ, Kushitor D, Bonney EY, Ofori SB, Kiyono H, Ishikawa K, Ampofo WK, Matano T. Longitudinal analysis of microbiome composition in Ghanaians living with HIV-1. Front Microbiol. 2024 Feb 15;15:1359402. doi: 10.3389/fmicb.2024.1359402. PMID: 38426062; PMCID: PMC10902004.
- Buzun E, Hsu CY, Sejane K, Oles RE, Vasquez Ayala A, Loomis LR, Zhao J, Rossitto LA, McGrosso DM, Gonzalez DJ, Bode L, Chu H. A bacterial sialidase mediates early-life colonization by a pioneering gut commensal. Cell Host Microbe. 2024 Feb 14;32(2):181-190.e9. doi: 10.1016/j.chom.2023.12.014.
- Ndukwe SO, Patel H, Shelton B, Concha-Garcia S, Dullano C, Solso S, Hendrickx S, Riggs PK, Villa TJ, Kaytes A, Taylor J, Little SJ, Lessard D, Arora AK, Costiniuk CT, Eskaf S, Smith DM, Gianella S, Dubé K. People with HIV at the end-of-life and their next-of-kin/loved ones are willing to participate in interventional HIV cure-related research. AIDS. 2024 Feb 1;38(2):235-243. doi: 10.1097/QAD.0000000000003754.
- 猪飼朋音, 後藤義幸, 腸内細菌によって誘導されるTh17細胞と自己免疫疾患, アレルギーの臨床, 2024年, 44卷, 2号, p28-33.
- Sun X, Hosomi K, Shimoyama A, Yoshii K, Saika A, Yamaura H, Nagatake T, Kiyono H, Fukase K, Kunisawa J. Alcaligenes lipid A functions as a superior mucosal adjuvant to monophosphoryl lipid A via the recruitment and activation of CD11b+ dendritic cells in nasal tissue. Int Immunol. 2024 Jan 29;36(1):33-43. doi: 10.1093/intimm/dxad045.
- Ohashi K, Nishito Y, Fukuda H, Sadahiro R, Yoshida Y, Watanabe SI, Motoi N, Sonobe Y, Mizuno H, Tsunoda H, Tatsumi K, Suzuki T, Ochiai A, Aoki K. Neutrophil-to-lymphocyte ratio is a prognostic factor reflecting immune condition of tumor microenvironment in squamous cell lung cancer. Sci Rep. 2024 Jan 3;14(1):429. doi: 10.1038/s41598-023-50378-9.
- Vasquez Ayala A, Hsu CY, Oles RE, Matsuo K, Loomis LR, Buzun E, Carrillo Terrazas M, Gerner RR, Lu HH, Kim S, Zhang Z, Park JH, Rivaud P, Thomson M, Lu LF, Min B, Chu H. Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice. J Exp Med. 2024 Jan 1;221(1):e20230063. doi: 10.1084/jem.20230063.
- 森 大地、後藤 義幸, ILC3による腸管上皮細胞のフコシル化誘導, 医学のあゆみ, 2024年. 288卷. 1号. p85-89.
- Itoh T, Kawasaki T, Kaiho T, Shikano K, Naito A, Abe M, Suzuki H, Ota M, Yoshino I, Suzuki T. Long-term nintedanib treatment for progressive pulmonary fibrosis associated with Hermansky-Pudlak syndrome type 1 followed by lung transplantation. Respir Investig. 2024 Jan;62(1):176-178. doi: 10.1016/j.resinv.2023.12.007.
- Murai Y, Sakao S, Kure F, Kawasaki T, Maruyama M, Suzuki H, Yoshino I, Suzuki T. Reduction of mycophenolate mofetil dosage to limit prolonged viral shedding in solid organ transplant recipients with COVID-19: Two case reports. Respir Investig. 2024 Jan;62(1):98-101. doi: 10.1016/j.resinv.2023.10.006.
- Kuboyama-Sasaki A, Takahashi Y, Xia C, Hiro K, Kobayashi T, Ohdan H, Shimizu M, Yamauchi Y, Kiyono H, Sato R. Establishment of a cell culture platform for human liver organoids and its application for lipid metabolism research. Biotechnol J. 2024 Jan;19(1):e2300365. doi: 10.1002/biot.202300365.
- Kan-O K, Noda T, Ogata H, Masaki K, Nishioka Y, Myojin T, Adachi T, Morita H, Imamura T, Tamari M, Kainuma K, ENGAGE NDB Task Force. Insights from the trends of omalizumab and mepolizumab utilization in patients with asthma: A population-based cohort study using the National Database in Japan. Respiratory investigation. 2024 Jan;62(1):113-120. doi: 10.1016/j.resinv.2023.11.003.
- Muraoka D, Moi ML, Muto O, Nakatsukasa T, Deng S, Takashima C, Yamaguchi R, Sawada SI, Hayakawa H, Nguyen TTN, Haseda Y, Soga T, Matsushita H, Ikeda H, Akiyoshi K, Harada N. Low-frequency CD8+ T cells induced by SIGN-R1+ macrophage-targeted vaccine confer SARS-CoV-2 clearance in mice. NPJ Vaccines. 2024 Sep 18;9(1):173. doi: 10.1038/s41541-024-00961-6. PMID: 39294173; PMCID: PMC11411095.
- Enveloped Viral Replica Equipped with Spike Protein Derived from SARS-CoV-2.
Furukawa H, Nakamura S, Mizuta R, Sakamoto K, Inaba H, Sawada SI, Sasaki Y, Akiyoshi K, Matsuura K.
ACS Synth Biol. 2024 Jul 19;13(7):2029-2037. doi: 10.1021/acssynbio.4c00165. Epub 2024 Jun 17. PMID: 38885191
- CCR4 predicts the efficacy of abatacept in rheumatoid arthritis patients through the estimation of Th17 and Treg cell abundance.
Tanaka S, Etori K, Hattori K, Tamura J, Ikeda K, Kageyama T, Meguro K, Iwamoto T, Iwata A, Furuta S, Suto A, Suzuki K, Nakajima H.
Mod Rheumatol. 2024 Jul 6;34(4):700-704. doi: 10.1093/mr/road077. PMID: 37522614
- Stage-specific GATA3 induction promotes ILC2 development after lineage commitment.
Furuya H, Toda Y, Iwata A, Kanai M, Kato K, Kumagai T, Kageyama T, Tanaka S, Fujimura L, Sakamoto A, Hatano M, Suto A, Suzuki K, Nakajima H.
Nat Commun. 2024 Jul 5;15(1):5610. doi: 10.1038/s41467-024-49881-y. PMID: 38969652
- A distal enhancer of GATA3 regulates Th2 differentiation and allergic inflammation.
Kumagai T, Iwata A, Furuya H, Kato K, Okabe A, Toda Y, Kanai M, Fujimura L, Sakamoto A, Kageyama T, Tanaka S, Suto A, Hatano M, Kaneda A, Nakajima H.
Proc Natl Acad Sci U S A. 2024 Jul 2;121(27):e2320727121. doi: 10.1073/pnas.2320727121. Epub 2024 Jun 26. PMID: 38923989
- Amphiregulin-producing TH2 cells facilitate esophageal fibrosis of eosinophilic esophagitis.
Kaneko T, Iwamura C, Kiuchi M, Kurosugi A, Onoue M, Matsumura T, Chiba T, Nakayama T, Kato N, Hirahara K.
J Allergy Clin Immunol Glob. 2024 Jun 4;3(3):100287. doi: 10.1016/j.jacig.2024.100287. eCollection 2024 Aug. PMID: 39040657
- Cationic Glucan Dendrimer Gel-Mediated Local Delivery of Anti-OC-STAMP-siRNA for Treatment of Pathogenic Bone Resorption.
Yamamoto K, Sawada SI, Shindo S, Nakamura S, Kwon YM, Kianinejad N, Vardar S, Hernandez M, Akiyoshi K, Kawai T.
Gels. 2024 May 31;10(6):377. doi: 10.3390/gels10060377. PMID: 38920924
- Memory CD8 T cells are vulnerable to chronic IFN-γ signals but not to CD4 T cell deficiency in MHCII-deficient mice.
Setoguchi R, Sengiku T, Kono H, Kawakami E, Kubo M, Yamamoto T, Hori S.
Nat Commun. 2024 May 28;15(1):4418. doi: 10.1038/s41467-024-48704-4. PMID: 38806459
- Soy sauce-like seasoning enhances the growth of Agathobacter rectalis and the production of butyrate, propionate, and lactate.
Hayashi K, Uchida R, Horiba T, Kawaguchi T, Gomi K, Goto Y.
Biosci Microbiota Food Health. 2024;43(3):275-281. doi: 10.12938/bmfh.2023-103. Epub 2024 Apr 29. PMID: 38966053
- Dynamic diversity of SARS-CoV-2 genetic mutations in a lung transplantation patient with persistent COVID-19.
Igari H, Sakao S, Ishige T, Saito K, Murata S, Yahaba M, Taniguchi T, Suganami A, Matsushita K, Tamura Y, Suzuki T, Ido E.
Nat Commun. 2024 Apr 29;15(1):3604. doi: 10.1038/s41467-024-47941-x. PMID: 38684722
- Suppression of Type I Interferon Signaling in Myeloid Cells by Autoantibodies in Severe COVID-19 Patients.
Aoki A, Iwamura C, Kiuchi M, Tsuji K, Sasaki A, Hishiya T, Hirasawa R, Kokubo K, Kuriyama S, Onodera A, Shimada T, Nagaoka T, Ishikawa S, Kojima A, Mito H, Hase R, Kasahara Y, Kuriyama N, Nakamura S, Urushibara T, Kaneda S, Sakao S, Nishida O, Takahashi K, Kimura MY, Motohashi S, Igari H, Ikehara Y, Nakajima H, Suzuki T, Hanaoka H, Nakada TA, Kikuchi T, Nakayama T, Yokote K, Hirahara K.
J Clin Immunol. 2024 Apr 22;44(4):104. doi: 10.1007/s10875-024-01708-7. PMID: 38647550
- Effects of Anti-Fibrotic Drugs on Transcriptome of Peripheral Blood Mononuclear Cells in Idiopathic Pulmonary Fibrosis.
Ishii D, Kawasaki T, Sato H, Tatsumi K, Imamoto T, Yoshioka K, Abe M, Hasegawa Y, Ohara O, Suzuki T.
Int J Mol Sci. 2024 Mar 28;25(7):3750. doi: 10.3390/ijms25073750. PMID: 38612561
- Functional roles of CD26/DPP4 in lipopolysaccharide-induced lung injury.
Sato S, Kawasaki T, Hatano R, Koyanagi Y, Takahashi Y, Ohnuma K, Morimoto C, Dudek SM, Tatsumi K, Suzuki T.
Am J Physiol Lung Cell Mol Physiol. 2024 May 1;326(5):L562-L573. doi: 10.1152/ajplung.00392.2022. Epub 2024 Mar 12. PMID: 38469626
- Physiological and immunological barriers in the lung.
Kageyama T, Ito T, Tanaka S, Nakajima H.
Semin Immunopathol. 2024 Jan;45(4-6):533-547. doi: 10.1007/s00281-024-01003-y. Epub 2024 Mar 7. PMID: 38451292
- [INTESTINAL ENVIRONMENT AND ASTHMA].
Ito T, Ohno H.
Arerugi. 2024;73(5):395-398. doi: 10.15036/arerugi.73.395. PMID: 39010198
- Immunogenicity and influence on disease activity of recombinant zoster vaccine in patients with rheumatoid arthritis treated with DMARDs.
Kojima S, Iwamoto T, Kobayashi Y, Kato M, Takizawa F, Ida T, Suzuki J, Toda Y, Miyachi K, Iwata A, Furuta S, Ikeda K, Nakajima H.
RMD Open. 2024 Feb 21;10(1):e003902. doi: 10.1136/rmdopen-2023-003902. PMID: 38388170
- Reduced-dose versus high-dose glucocorticoids added to rituximab on remission induction in ANCA-associated vasculitis: predefined 2-year follow-up study.
Furuta S, Nakagomi D, Kobayashi Y, Hiraguri M, Sugiyama T, Amano K, Umibe T, Kono H, Kurasawa K, Kita Y, Matsumura R, Kaneko Y, Ninagawa K, Hiromura K, Kagami SI, Inaba Y, Hanaoka H, Ikeda K, Nakajima H; LoVAS collaborators.
Ann Rheum Dis. 2024 Jan 2;83(1):96-102. doi: 10.1136/ard-2023-224343. PMID: 37734880
- Eosinophils Contribute to Oral Tolerance via Induction of RORγt-Positive Antigen-Presenting Cells and RORγt-Positive Regulatory T Cells.
Kurihara S, Suzuki K, Yokota M, Ito T, Hayashi Y, Kikuchi R, Kageyama T, Meguro K, Tanaka S, Iwata A, Goto Y, Suto A, Nakajima H.
Biomolecules. 2024 Jan 10;14(1):89. doi: 10.3390/biom14010089. PMID: 38254689
- Okaya T, Kawasaki T, Sato S, Koyanagi Y, Tatsumi K, Hatano R, Ohnuma K, Morimoto C, Kasuya Y, Hasegawa Y, Ohara O, Suzuki T. Functional Roles of CD26/DPP4 in Bleomycin-Induced Pulmonary Functional Roles of CD26/DPP4 in Bleomycin-Induced Pulmonary Hypertension Associated with Interstitial Lung Disease.
Okaya T, Kawasaki T, Sato S, Koyanagi Y, Tatsumi K, Hatano R, Ohnuma K, Morimoto C, Kasuya Y, Hasegawa Y, Ohara O, Suzuki T.
Int J Mol Sci. 2024 Jan 6;25(2):748. doi: 10.3390/ijms25020748. PMID: 38255821
- Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity.
Zhang Z, Tanaka I, Nakahashi-Ouchida R, Ernst PB, Kiyono H, Kurashima Y.
Semin Immunopathol. 2024 Jan;45(4-6):493-507. doi: 10.1007/s00281-023-00999-z. Epub 2024 Jan 3. PMID: 38170255
2023年
- 岩村千秋、平原潔、中山俊憲 COVID-19重症化マーカーMyl9の可能性 呼吸器内科 44(6):679-685 (2023)12月28日
- Imamoto T, Kawasaki T, Sato H, Tatsumi K, Ishii D, Yoshioka K, Hasegawa Y, Ohara O, Suzuki T. Different Transcriptome Features of Peripheral Blood Mononuclear Cells in Non-Emphysematous Chronic Obstructive Pulmonary Disease. Int J Mol Sci.2023 Dec 20;25(1):66. doi: 10.3390/ijms25010066.
- Kumagai J, Kiuchi M, Kokubo K, Yagyu H, Nemoto M, Tsuji K, Nagahata K, Sasaki A, Hishiya T, Onoue M, Shinmi R, Sonobe Y, Iinuma T, Yonekura S, Shinga J, Hanazawa T, Koseki H, Nakayama T, Yokote K, Hirahara K. The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells. Proc. Natl. Acad. Sci. USA 2023 Dec 5;120(49):e2302903120. doi: 10.1073/pnas.2302903120.
- Akasaki Y, Iwagami M, Sung J, Nagino K, Adachi T, Morita H, Tamari M, Kainuma K, Kan-O K, Ogata H, Sakashita M, Futamura M, Kurashima Y, Nakajima S, Masaki K, Ogawa Y, Sato S, Miyagawa A, Midorikawa‐Inomata A, Fujimoto K, Okumura Y, Fujio K, Huang T, Hirosawa K, Morooka Y, Nakao S, Murakami A, Kobayashi H, Inomata T. Impact of COVID‐19 on care‐seeking patterns for hay fever in Japan: A retrospective claims database cohort study. Allergy.2023 Nov 15. doi: 10.1111/all.15947.
- Kawata N, Iwao Y, Matsuura Y, Suzuki M, Ema R, Sekiguchi Y, Sato H, Nishiyama A, Nagayoshi M, Takiguchi Y, Suzuki T, Haneishi H. Prediction of oxygen supplementation by a deep-learning model integrating clinical parameters and chest CT images in COVID-19. Jpn J Radiol. 2023 Dec;41(12):1359-1372. doi: 10.1007/s11604-023-01466-3.
- Ogawa H, Takeda K, Yoneoka R, Shikano K, Abe M, Kasai H, Suzuki T. Severe Bacterial Pneumonia due to Legionella longbeachae Transmitted from Potting Soil in Japan. Intern Med. 2023 Nov 27. doi: 10.2169/internalmedicine.2590-23.
- Misawa S, Denda T, Kodama S, Suzuki T, Naito Y, Kogawa T, Takada M, Suichi T, Shiosakai K, Kuwabara S; MiroCIP study group. Efficacy and safety of mirogabalin for chemotherapy-induced peripheral neuropathy: a prospective single-arm trial (MiroCIP study). BMC Cancer. 2023 Nov 11;23(1):1098. doi: 10.1186/s12885-023-11560-4.
- Etori K, Tanaka S, Tamura J, Hattori K, Kagami SI, Nakamura J, Ohtori S, Nakajima H. Fibroblast growth factor receptor 1 as a potential marker of terminal effector peripheral T helper cells in rheumatoid arthritis patients. Rheumatology (Oxford). 2023 Nov 2;62(11):3763-3769. doi: 10.1093/rheumatology/kead220.
- McCuaig B, Goto Y. Immunostimulating Commensal Bacteria and Their Potential Use as Therapeutics, Int J Mol Sci. 2023 Oct 27;24(21):15644. doi: 10.3390/ijms242115644.
- 清野宏, 特集『ワクチン研究開発拠点』,“千葉大学未来粘膜ワクチン研究開発シナジー拠点（cSIMVa）：有効で安全・安心な粘膜ワクチン開発研究を目指す”,JSI Newsletter 32 (#1): 6. 2023年10月20日.
- Kawame C, Kasai H, Shiohira S, Sugiura T, Shiko Y, Sakao S, Suzuki T. Role of Fibrin Monomer Complex in Coronavirus Disease 2019 for Venous Thromboembolism and the Prognosis. Intern Med. 2023 Oct 15;62(20):2941-2948. doi: 10.2169/internalmedicine.1322-22.
- Kitahara S, Abe M, Kono C, Sakuma N, Ishii D, Kawasaki T, Ikari J, Suzuki T. Prognostic impact of the cross-sectional area of the erector spinae muscle in patients with pleuroparenchymal fibroelastosis. Sci Rep. 2023 Oct 12;13(1):17289. doi: 10.1038/s41598-023-44138-y.
- Iinuma T, Yonekura S, Hirahara K, Kurita J, Yoneda R, Arai T, Sonobe Y, Shinmi R, Okamoto Y, Hanazawa T. Differences in the expression of multidrug resistance proteins in chronic rhinosinusitis according to endotype. Allergol Int. 2023 Oct;72(4):564-572. doi: 10.1016/j.alit.2023.03.008.
- Suga K, Kiuchi M, Kageyama T, Kokubo K, Tanaka S, Iwata A, Suzuki K, Hirahara K, Nakajima H. Single-cell RNA sequencing of peripheral blood mononuclear cells from Kimura disease patient successfully treated with dupilumab. Allergol Int. 2023 Oct;72(4):610-613. doi: 10.1016/j.alit.2023.06.002.
- Tsai CJY, Loh JMS, Fujihashi K, Kiyono H. Immunology of mucosal surfaces. Mucosal vaccination: onward and upward. Expert Rev. Vaccines. 2023.Jan-Dec;22(1):885-899. doi: 10.1080/14760584.2023.2268724.
- Tsuyuzaki K, Yoshida N, Ishikawa T, Goshima Y, Kawakami E. Non-negative tensor factorization workflow for time series biomedical data. STAR Protocols. 2023 Sep 15;4(3):102318, doi:10.1016/j.xpro.2023.102318.
- Matsumoto N, Kurokawa S, Tamiya S, Nakamura Y, Sakon N, Okitsu S, Ushijima H, Yuki Y, Kiyono H, Sato S. Replication of Human Sapovirus in Human-Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Cells.Viruses. 2023 Sep 15;15(9):1929. doi: 10.3390/v15091929.
- Kuriyama A, Kasai H, Sugiura T, Nagata J, Naito A, Sekine A, Shigeta A, Sakao S, Ishida K, Matsumiya G, Tanabe N, Suzuki T. Clinical significance of lung cross-sectional area measured by computed tomography in chronic thromboembolic pulmonary hypertension: The correlation with pulmonary hemodynamics and the limitations. Pulm Circ. 2023 Sep 11;13(3):e12287. doi: 10.1002/pul2.12287.
- Ikeda H, Nagasaki J, Shimizu D, Katsuya Y, Horinouchi H, Hosomi Y, Tanji E, Iwata T, Itami M, Kawazu M, Ohe Y, Suzuki T, Togashi Y. Immunologic Significance of CD80/CD86 or Major Histocompatibility Complex-II Expression in Thymic Epithelial Tumors. JTO Clin Res Rep. 2023 Sep 9;4(10):100573. doi: 10.1016/j.jtocrr.2023.100573.
- Amai M, Nojima M, Yuki Y, Kiyono H, Nagamura F. A review of criteria strictness in "Toxicity Grading Scale for Healthy Adult and Adolescent Volunteers Enrolled in Preventive Vaccine Clinical Trials". Vaccine. 2023 Aug 31;41(38):5622-5629. doi: 10.1016/j.vaccine.2023.07.072.
- Ishikawa J, Suto A, Abe K, Hayashi Y, Suga K, Tanaka S, Kageyama T, Iwata A, Suzuki K, Suzuki K, Nakajima H. IL-21 is required for the maintenance and pathogenesis of murine Vγ4+ IL-17-producing γδT cells. Front Immunol. 2023 Aug 18:14:1211620. doi: 10.3389/fimmu.2023.1211620.
- Hirama R, Takeda K, Sakao S, Kasai H, Miyata S, Shikano K, Naito A, Abe M, Kawasaki T, Shigeta A, Nakada TA, Igari H, Suzuki T. A Comparison of Clinical Presentations in Coronavirus Disease 2019 Caused by Different Omicron Variants in Japan: A Retrospective Study. Intern Med. 2023 Aug 15;62(16):2321-2328. doi: 10.2169/internalmedicine.1399-22.
- Koyama-Nasu R, Kimura MY, Kiuchi M, Aoki A, Wang Y, Mita Y, Hasegawa I, Endo Y, Onodera A, Hirahara K, Motohashi S, Nakayama T. CD69 imposes tumor-specific CD8+ T cell fate in tumor-draining lymph nodes. Cancer Immunology Research. 2023 Aug 3;11(8):1085-1099. doi: 10.1158/2326-6066.CIR-22-0406.
- Shikano K, Abe M, Hirama R, Kitahara S, Maruyama K, Horiuchi D, Sakuma N, Ishii D, Kawasaki T, Nakamura H, Suzuki T. A retrospective comparison between digital to conventional drainage systems for secondary spontaneous pneumothorax related to diffuse interstitial lung disease. Clin Respir J. 2023 Aug;17(8):733-739. doi: 10.1111/crj.13654.
- Sato Y, Silina K, van den Broek M, Hirahara K, and Yanagita M. The roles of tertiary lymphoid structures in chronic diseases. Nat. Rev. Nephrol. 2023 Aug;19(8):525-537. doi: 10.1038/s41581-023-00706-z.
- Yuki Y, Harada N, Sawada SI, Uchida Y, Nakahashi-Ouchida R, Mori H, Yamanoue T, Machita T, Kanazawa M, Fukumoto D, Ohba H, Miyazaki T, Akiyoshi K, Fujihashi K, and Kiyono H. Biodistribution assessment of cationic pullulan nanogel, a nasal vaccine delivery system, in mice and non-human primates. Vaccine 2023. Jul 31;41(34):4941-4949. doi: 10.1016/j.vaccine.2023.06.065.
- Umemoto S, Nakahashi-Ouchida R, Yuki Y, Kurokawa S, Machita T, Uchida Y, Mori H, Yamanoue T, Shibata T, Sawada S, Ishige K, Hirano T, Fujihashi K, Akiyoshi K, Kurashima Y, Tokuhara D, Ernst PB, Suzuki M, Kiyono H. Cationic-nanogel nasal vaccine containing the ectodomain of RSV-small hydrophobic protein induces protective immunity in rodents. NPJ vaccines.2023 Jul 24;8(1):106. doi: 10.1038/s41541-023-00700-3.
- Takeda K, Kasai H, Tajima H, Furukawa Y, Imaeda T, Suzuki T, Ito S. Mixed-methods education of mechanical ventilation for residents in the era of the COVID-19 pandemic: Preliminary interventional study. PLoS One. 2023 Jul 13;18(7):e0287925. doi: 10.1371/journal.pone.0287925.
- Sanada TJ, Hosomi K, Park J, Naito A, Sakao S, Tanabe N, Kunisawa J, Tatsumi K, Suzuki T. Partially hydrolyzed guar gum suppresses the progression of pulmonary arterial hypertension in a SU5416/hypoxia rat model. Pulm Circ. 2023 Jul 12;13(3):e12266. doi: 10.1002/pul2.12266.
- Iida K, Suga K, Suzuki K, Kurihara S, Yabe Y, Kageyama T, Meguro K, Tanaka S, Iwata A, Suto A, Nakajima H. A role of Achaete-scute complex homolog 2 in T follicular regulatory cell development. Biochem Biophys Res Commun. 2023 Jul 5:664:9-19. doi: 10.1016/j.bbrc.2023.04.065.
- Onodera A, Kokubo K, Okano M, Onoue M, Kiuchi M, Iwamura C, Iinuma T, Kimura MY, Ebihara N, Hanazawa T, Nakayama T, Hirahara K. Pathogenic helper T cells as the novel therapeutic targets for immune-mediated intractable diseases. Pharmacol Ther. 2023 Jul:247:108445. doi: 10.1016/j.pharmthera.2023.108445.
- Suzuki E, Kawata N, Shimada A, Sato H, Anazawa R, Suzuki M, Shiko Y, Yamamoto M, Ikari J, Tatsumi K, Suzuki T. Prognostic Nutritional Index (PNI) as a Potential Prognostic Tool for Exacerbation of COPD in Elderly Patients. Int J Chron Obstruct Pulmon Dis. 2023 Jun 7;18:1077-1090. doi: 10.2147/COPD.S385374.
- Abana CZ, Kushitor DK, Asigbee TW, Parbie PK, Ishikawa K, Kiyono H, Mizutani T, Siaw S, Ofori SB, Addo-Tetebo G, Ansong MRD, Williams M, Morton S, Danquah G, Matano T, Ampofo WK, Bonney EY. Community based multi-disease health screening as an opportunity for early detection of HIV cases and linking them to care. BMC Public Health. 2023 Jun 1;23(1):1051. doi: 10.1186/s12889-023-15948-6.
- 清野宏,“粘膜ワクチン開発を目指す”ウイルス 73 (#1) :125-129, 日本ウイルス学会誌,2023年6月.
- Hoque SA, Kotaki T, Pham NTK, Onda Y, Okitsu S, Sato S, Yuki Y, Kobayashi T, Maneekarn N, Kiyono H, Hayakawa S, Ushijima H. Genotype Diversity of Enteric Viruses in Wastewater Amid the COVID-19 Pandemic. Food Environ Virol. 2023 Jun;15(2):176-191. doi: 10.1007/s12560-023-09553-4.
- Suga K, Suto A, Tanaka S, Sugawara Y, Kageyama T, Ishikawa J, Sanayama Y, Ikeda K, Furuta S, Kagami SI, Iwata A, Hirose K, Suzuki K, Ohara O, Nakajima H. TAp63, a methotrexate target in CD4+ T cells, suppresses Foxp3 expression and exacerbates autoimmune arthritis. JCI Insight. 2023 May 22;8(10):e164778. doi: 10.1172/jci.insight.164778.
- Yamao Y, Oami T, Kawakami E, Nakada TA. Protocol to acquire time series data on adverse reactions following vaccination using a smartphone or web-based platform.STAR protocols. 2023 May 5;4(2): 102284, doi:10.1016/j.xpro.2023.102284
- Miyashita K, Hozumi H, Inoue Y, Suzuki T, Suda T. Nationwide survey of adult patients with pulmonary alveolar proteinosis using the National Database of designated intractable diseases of Japan. Respir Investig. 2023 May;61(3):364-370. doi: 10.1016/j.resinv.2023.02.011.
- 幸義和, 清野宏, 米の機能性食品化と新規利用技術・高度加工技術の開発―食糧, 食品素材, 機能性食品, 工業原料, 医薬品原料としての米―, 第1節 医療用, 第１項 米によるコレラワクチンの開発, P.469-480, NTS Co., ISBN:978-4-86043-844-9 C3050, 2023年5月.
- Kanazawa J, Rawlings SA, Hendrickx S, Gianella S, Concha-Garcia S, Taylor J, Kaytes A, Patel H, Ndukwe S, Little SJ, Smith D, Dubé K. Lessons learned from the Last Gift study: ethical and practical challenges faced while conducting HIV cure-related research at the end of life. J Med Ethics. 2023 May;49(5):305-310. doi: 10.1136/medethics-2021-107512.
- Takahashi Y, Inoue Y, Sato S, Okabe T, Kojima H, Kiyono H, Shimizu M, Yamauchi Y, Sato R. Drug cytotoxicity screening using human intestinal organoids propagated with extensive cost-reduction strategies. Sci Rep. 2023 Apr 3;13(1):5407. doi: 10.1038/s41598-023-32438-2.
- Sun X, Hosomi K, Shimoyama A, Yoshii K, Lan H, Wang Y, Yamaura H, Nagatake T, Ishii KJ, Akira S, Kiyono H, Fukase K, Kunisawa J. TLR4 agonist activity of Alcaligenes lipid a utilizes MyD88 and TRIF signaling pathways for efficient antigen presentation and T cell differentiation by dendritic cells. Int Immunopharmacol. 2023 Apr;117:109852. doi: 10.1016/j.intimp.2023.109852.
- Iwata A, Toda Y, Furuya H, Nakajima H. Group 2 innate lymphoid cells in human asthma. Allergol Int. 2023 Apr;72(2):194-200. doi: 10.1016/j.alit.2022.12.001.
- Koyanagi Y, Kawasaki T, Kasuya Y, Hatano R, Takahashi Y, Sato S, Ohnuma K, Morimoto C, Tatsumi K, Suzuki T. CD26/DPP4 and fibroblast activation in mouse bleomycin-induced pulmonary fibrosis.Physiol Rep. 2023 Mar;11(6):e15645. doi: 10.14814/phy2.15645.
- 倉島洋介. 腸内細菌の制御を担う膵臓の役割. 胆と膵. 44(3) :229-234. 2023. 医学図書出版
- Miyachi K, Iwamoto T, Kojima S, Ida T, Suzuki J, Yamamoto T, Mimura N, Sugiyama T, Tanaka S, Furuta S, Ikeda K, Suzuki K, Niewold TB, Nakajima H. Relationship of systemic type I interferon activity with clinical phenotypes, disease activity, and damage accrual in systemic lupus erythematosus in treatment-naive patients: a retrospective longitudinal analysis. Arthritis Res Ther. 2023 Feb 17;25(1):26. doi: 10.1186/s13075-023-03010-0.
- Koyanagi K, Kataoka K, Yoshimatsu H, Fujihashi K, Miyake T. Human salivary protein-derived peptides specific-salivary SIgA antibodies enhanced by nasal double DNA adjuvant in mice play an essential role in preventing Porphyromonas gingivalis colonization: an in-vitro study. BMC Oral Health. 2023 Feb 24; 23(1):123. doi: 10.1186/s12903-023-02821-6.
- Hoque SA, Kotaki T, Pham NTK, Onda Y, Okitsu S, Sato S, Yuki Y, Kobayashi T, Maneekarn N, Kiyono H, Hayakawa S, Ushijima H. Abundance of viral gastroenteritis before and after the emergence of COVID-19: Molecular evidence on wastewater. J Infect. 2023 Feb;86(2):154-225. doi: 10.1016/j.jinf.2022.11.007.
- Rios-Covian D, Butcher LD, Ablack AL, den Hartog G, Matsubara MT, Ly H, Oates AW, Xu G, Fisch KM, Ahrens ET, Toden S, Brown CC, Kim K, Le D, Eckmann L, Dhar B, Izumi T, Ernst PB, Crowe SE. A Novel Hypomorphic Apex1 Mouse Model Implicates Apurinic/Apyrimidinic Endonuclease 1 in Oxidative DNA Damage Repair in Gastric Epithelial Cells.Antioxid Redox Signal. 2023 Jan;38(1-3):183-197. doi: 10.1089/ars.2021.0119.
- 倉島洋介, 清野宏. マイクロバイオームと膵腸連関. 肝胆膵. 86(3):369-376. 2023. アークメディア
- Hosomi K, Shimoyama A, Hinenoya A, Hatanaka N, Noguchi T, Ebina H, Tojima Y, Furuta M, Kondoh M, Kiyono H, Yamasaki S, Fukase K, Kunisawa J. Endotoxin-free Stx2B-C-CPE vaccine and its optimized adjuvant regimen for preventing food poisoning. Front Biosci (Landmark Ed). 2023 Jan 17;28(1):15. doi: 10.31083/j.fbl2801015.
- Kasuya T, Tanaka S, Tamura J, Etori K, Shoda J, Hattori K, Endo Y, Kitajima M, Kageyama T, Iwamoto T, Yokota M, Iwata A, Suto A, Suzuki K, Suzuki H, Ziegler SF, Nakajima H. Epithelial cell-derived cytokine TSLP activates regulatory T cells by enhancing fatty acid uptake. Sci Rep. 2023 Jan 30;13(1):1653. doi: 10.1038/s41598-023-28987-1.
- Kokubo K, Hirahara K, Kiuchi M, Tsuji K, Shimada Y, Sonobe Y, Shinmi R, Hishiya T, Iwamura C, Onodera A, Nakayama T. Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism. Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2218345120. doi: 10.1073/pnas.2218345120.
- Kobayashi H, Kimura MY, Hasegawa I, Suganuma E, Ikehara Y, Azuma K, Ito T, Ebata R, Kurashima Y, Kawasaki Y, Shiko Y, Saito N, Iwase H, Lee Y, Noval Rivas M, Arditi M, Zuka M, Hamada H, Nakayama T. Increased Myosin light chain 9 expression during Kawasaki disease vasculitis.Front Immunol. 2023 Jan 6;13:1036672. doi: 10.3389/fimmu.2022.1036672.
- Tsai CJY, Loh JMS, Fujihashi K, Kiyono H. Immunology of mucosal surfaces. Mucosal vaccination: onward and upward. Expert Rev. Vaccines. 2023.Jan-Dec;22(1):885-899. doi: 10.1080/14760584.2023.2268724
2022年
- Yuki Y, Zuo F, Kurokawa S, Uchida Y, Sato S, Sakon N, Hammarström L, Kiyono H, Marcotte H. Lactobacilli as a vector for delivery of nanobodies against norovirus infection. Pharmaceutics. 2022 Dec 25;15(1):63. doi: 10.3390/pharmaceutics15010063.
- Mashimo Y, Yamazaki K, Kageyama T, Tanaka S, Taniguchi T, Matsushita K, Igari H, Hanaoka H, Yokote K, Nakajima H, Onouchi Y. Germline variants of IGHV3-53 / V3-66 are determinants of antibody responses to the BNT162b2 mRNA COVID-19 vaccine. J Infect. 2022 Dec;85(6):702-769. doi: 10.1016/j.jinf.2022.10.015.
- Baba H, Ikumi S, Aoyama S, Ishikawa T, Asai Y, Matsunaga N, Ohmagari N, Kanamori H, Tokuda K, Ueda T, Kawakami E. Statistical Analysis of Mortality Rates of Coronavirus Disease 2019 (COVID-19) Patients in Japan Across the 4C Mortality Score Risk Groups, Age Groups, and Epidemiological Waves: A Report From the Nationwide COVID-19 Cohort. Open Forum Infect Dis. 2022 Nov 24;10(1):ofac638. doi: 10.1093/ofid/ofac638.
- Nakahashi-Ouchida R, Fujihashi K, Kurashima Y, Yuki Y, Kiyono H. Nasal vaccines: solutions for respiratory infectious diseases. Trends Mol Med. 2023 Feb;29(2):124-140. doi: 10.1016/j.molmed.2022.10.009.
- 後藤 義幸 生体バリアと腸内細菌叢, 免疫系疾患, 実験医学別冊 改訂版 もっとよくわかる！腸内細菌叢 "もう1つの臓器"を知り、健康・疾患を制御する！ 福田真嗣（編） 2022年. p34-46, p84-86.
- Noguchi M, Shimizu M, Lu P, Takahashi Y, Yamauchi Y, Sato S, Kiyono H, Kishino S, Ogawa J, Nagata K, Sato R. Lactic acid bacteria-derived γ-linolenic acid metabolites are PPARδ ligands that reduce lipid accumulation in human intestinal organoids. J Biol Chem. 298:102534, November/2022. doi: 10.1016/j.jbc.2022. 102534.
- Ikeda K, Nakada T, Kageyama T, Tanaka S, Yoshida N, Ishikawa T, Goshima Y, Otaki N, Iwami S, Shimamura T, Taniguchi T, Igari H, Hanaoka H, Yokote K, Tsuyuzaki K, Nakajima H, Kawakami E. Detecting time-evolving phenotypic components of adverse reactions against BNT162b2 SARS-CoV-2 vaccine via non-negative tensor factorization.iScience. 2022 Oct 21;25(10):105237. doi: 10.1016/j.isci.2022.105237.
- 後藤 義幸 腸内細菌の遺伝子操A69:D89いて一遺伝子レベルでの機能解析が可能となる Microbiome Science 2022年 1卷 2号 p43-45.
- 平原潔、小久保幸太、中山俊憲 CD4陽性T細胞と肺の線維化 医学のあゆみ 283(1):4-9 (2022).
- Hashimoto Y, Eguchi A, Wei Y, Shinno-Hashimoto H, Fujita Y, Ishima T, Chang L, Mori C, Suzuki T, Hashimoto K. Antibiotic-induced microbiome depletion improves LPS-induced acute lung injury via gut-lung axis. Life Sci. 2022 Oct 15;307:120885. doi: 10.1016/j.lfs.2022.120885.
- Nishimura N, Yokota M, Kurihara S, Iwata A, Kageyama T, Ito T, Saku A, Maezawa Y, Hirose K, Nakajima H. Airway epithelial STAT3 inhibits allergic inflammation via upregulation of stearoyl-CoA desaturase 1. Allergol Int. 2022 Oct;71(4):520-527. doi: 10.1016/j.alit.2022.05.002.
- Adachi M, Taniguchi K, Hori H, Mizutani T, Ishizaka A, Ishikawa K, Matano T, Opare D, Arhin D, Asiedu FB, Ampofo WK, Yeboah DM, Koram KA, Anang AK, Kiyono H. Strengthening surveillance in Ghana against public health emergencies of international concern. Trop Med Health. 2022 Oct 28;50(1):81. doi: 10.1186/s41182-022-00473-w.