Achievements | 千葉大学未来粘膜ワクチン研究開発シナジー拠点（cSIMVa）

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知識基盤 / New Knowledge
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2025年

Koyama-Nasu R, Wang Y, Miyano H, Kimura MY. Differentiation of Cytotoxic CD8+ T Cell Subsets Under Tumor Progression: Can CD69 Be a New Therapeutic Target? Cancer Sci. 2025 Mar 25. doi: 10.1111/cas.70055.
Okuda R, Ogura T, Hisata S, Baba T, Kondoh Y, Suda T, Johkoh T, Iwasawa T, Tomioka H, Bando M, Azuma A, Inoue Y, Ishikawa N, Arai N, Takihara T, Hamaguchi M, Arai T, Nakamura Y, Miyamoto A, Tomii K, Miyazaki Y, Chiba H, Ishii H, Hamada N, Terasaki Y, Fukuoka J, Sakai F, Egashira R, Fujimoto K, Sumikawa H, Suzuki T, Sakamoto S, Nishioka Y, Hattori N, Hashimoto N, Morita S, Ichihara N, Miyata H, Hagiwara K, Kobayashi K, Nukiwa T; JIPS registry collaborators. Prognostic prediction for newly diagnosed patients with idiopathic interstitial pneumonia: JIPS Registry (NEJ030). Respir Investig. 2025 Mar 17;63(3):365-372. doi: 10.1016/j.resinv.2025.02.009.
Li Y, Ascui G, Dicker M, Riffelmacher T, Chandra V, Schmiedel B, Chou TF, Vijayanand P, Kronenberg M. Crohn's Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function. Nat Commun. 2025 Mar 15;16(1):2577. doi: 10.1038/s41467-025-57744-3.
Jena PK, Wakita D, Gomez AC, Carvalho TT, Atici AE, Aubuchon E, Narayanan M, Lee Y, Fishbein MC, Takasato Y, Kurashima Y, Kiyono H, Cani PD, de Vos WM, Underhill DM, Devkota S, Chen S, Shimada K, Crother TR, Arditi M, Noval Rivas M. Intestinal Microbiota Contributes to the Development of Cardiovascular Inflammation and Vasculitis in Mice. Circ Res. 2025 Mar 3. doi: 10.1161/CIRCRESAHA.124.325079. Epub ahead of print. PMID: 40026151.
Shukuya T, Asao T, Goto Y, Mimori T, Takayama K, Kaira K, Tanaka H, Ko R, Amano Y, Tachihara M, Suzuki T, Tanizaki J, Sugawara S, Zenke Y, Shirai Y, Hayashi T, Mori K, Takahashi K. Activity and safety of atezolizumab plus carboplatin and paclitaxel in patients with advanced or recurrent thymic carcinoma (MARBLE): a multicentre, single-arm, phase 2 trial. Lancet Oncol. 2025 Mar;26(3):331-342. doi: 10.1016/S1470-2045(25)00001-4.
Kronenberg M, Riffelmacher T. Defenders or defectors: mucosal-associated invariant T cells in autoimmune diseases. Curr Opin Immunol. 2025 Apr;93:102542. doi: 10.1016/j.coi.2025.102542. Epub 2025 Feb 27.
Nishimura K, Aoki T, Kobayashi M, Takami M, Ozaki K, Ogawa K, Hongxuan W, Shimizu D, Katsumi D, Yoshizawa H, Komatsu S, Takatani T, Hirahara K, Koseki H, Hishiki T, Motohashi S. Antibody-Dependent Cellular Cytotoxicity of iPS Cell-Derived Natural Killer T Cells by Anti-GD2 mAb for Neuroblastoma. Cancer Sci. 2025 Apr;116(4):884-896. doi: 10.1111/cas.70008. Epub 2025 Feb 6.
Kronenberg M, Ascui G. The α glycolipid rules the NKT cell TCR. J Exp Med. 2025 Feb 3;222(2):e20242099. doi: 10.1084/jem.20242099.
Ida T, Furuta S, Fujiwara M, Hiraguri M, Hirose K, Ikeda K, Iwamoto T, Kagami SI, Kobayashi Y, Kurasawa K, Nakagomi D, Oya Y, Sanayama Y, Shimizu T, Tamachi T, Umibe T, Yasui M, Nakajima H. Short-term and long-term outcomes of patients with anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis. Rheumatology (Oxford). 2025 Feb 1;64(2):756-762. doi: 10.1093/rheumatology/keae011.
Ascui G, Cedillo-Castelan V, Mendis A, Phung E, Liu HY, Verstichel G, Chandra S, Murray MP, Luna C, Cheroutre H, Kronenberg M. Innateness transcriptome gradients characterize mouse T lymphocyte populations. J Immunol. 2025 Feb 1;214(2):223-237. doi: 10.1093/jimmun/vkae015.
Sugihara J, Iwamura C, Tateishi T, Hosoya T, Shimada S, Hirahara K, Yasuda S, Miyazaki Y. Prolonged high Myl9 levels are associated with the pathogenesis and respiratory symptom of post-acute COVID-19 syndrome: A 6-month follow-up study. Clinics (Sao Paulo). 2025 Jan 28;80:100584. doi: 10.1016/j.clinsp.2025.100584.
Ikeda H, Kawase K, Nishi T, Watanabe T, Takenaga K, Inozume T, Ishino T, Aki S, Lin J, Kawashima S, Nagasaki J, Ueda Y, Suzuki S, Makinoshima H, Itami M, Nakamura Y, Tatsumi Y, Suenaga Y, Morinaga T, Honobe-Tabuchi A, Ohnuma T, Kawamura T, Umeda Y, Nakamura Y, KiniwaＹ, Ichihara E, Hayashi H, Ikeda J, Hanazawa T, Toyooka S, Mano H, Suzuki T, Osawa T, Kawazu M, Togashi Y．Immune evasion through mitochondria transfer in the tumour microenvironment． 2025 Feb;638(8049):225-236. doi: 10.1038/s41586-024-08439-0. Epub 2025 Jan 22.
Abe K, Iwamoto T, Ikeda K, Sugiyama T, Furuta S, Saito G, Wakabayashi H, Nakajima H. Calcium pyrophosphate crystal arthritis associated with immune checkpoint inhibitor successfully treated with intra-articular glucocorticoid: A case report. Mod Rheumatol Case Rep. 2025 Jan 16;9(1):27-30. doi: 10.1093/mrcr/rxae029.
Ueki H, Wang IH, Kiso M, Horie K, Iida S, Mine S, Ujie M, Hsu HW, Wu CH, Imai M, Suzuki T, Kamitani W, Kawakami E, Kawaoka Y. Neutrophil adhesion to vessel walls impairs pulmonary circulation in COVID-19 pathology. Nat Commun. 2025 Jan 13;16(1):455. doi: 10.1038/s41467-024-55272-0.
Shionoya Y, Kasai H, Kono R, Hirama R, Ota M, Naito A, Abe M, Kawasaki T, Ikeda JI, Suzuki T．Mycobacterium goodii pulmonary disease with organizing pneumonia: A case report and review of literature．Respirol Case Rep. 2025 Jan 4;13(1):e70095. doi: 10.1002/rcr2.70095. eCollection 2025 Jan.

2024年

2023年

2022年

Yuki Y, Zuo F, Kurokawa S, Uchida Y, Sato S, Sakon N, Hammarström L, Kiyono H, Marcotte H. Lactobacilli as a vector for delivery of nanobodies against norovirus infection. Pharmaceutics. 2022 Dec 25;15(1):63. doi: 10.3390/pharmaceutics15010063.
Mashimo Y, Yamazaki K, Kageyama T, Tanaka S, Taniguchi T, Matsushita K, Igari H, Hanaoka H, Yokote K, Nakajima H, Onouchi Y. Germline variants of IGHV3-53 / V3-66 are determinants of antibody responses to the BNT162b2 mRNA COVID-19 vaccine. J Infect. 2022 Dec;85(6):702-769. doi: 10.1016/j.jinf.2022.10.015.
Baba H, Ikumi S, Aoyama S, Ishikawa T, Asai Y, Matsunaga N, Ohmagari N, Kanamori H, Tokuda K, Ueda T, Kawakami E. Statistical Analysis of Mortality Rates of Coronavirus Disease 2019 (COVID-19) Patients in Japan Across the 4C Mortality Score Risk Groups, Age Groups, and Epidemiological Waves: A Report From the Nationwide COVID-19 Cohort. Open Forum Infect Dis. 2022 Nov 24;10(1):ofac638. doi: 10.1093/ofid/ofac638.
Nakahashi-Ouchida R, Fujihashi K, Kurashima Y, Yuki Y, Kiyono H. Nasal vaccines: solutions for respiratory infectious diseases. Trends Mol Med. 2023 Feb;29(2):124-140. doi: 10.1016/j.molmed.2022.10.009.
後藤　義幸　生体バリアと腸内細菌叢, 免疫系疾患, 実験医学別冊　改訂版　もっとよくわかる！腸内細菌叢　"もう1つの臓器"を知り、健康・疾患を制御する！福田真嗣（編）　2022年. p34-46, p84-86.
Noguchi M, Shimizu M, Lu P, Takahashi Y, Yamauchi Y, Sato S, Kiyono H, Kishino S, Ogawa J, Nagata K, Sato R. Lactic acid bacteria-derived γ-linolenic acid metabolites are PPARδ ligands that reduce lipid accumulation in human intestinal organoids. J Biol Chem. 298:102534, November/2022. doi: 10.1016/j.jbc.2022. 102534.
Ikeda K, Nakada T, Kageyama T, Tanaka S, Yoshida N, Ishikawa T, Goshima Y, Otaki N, Iwami S, Shimamura T, Taniguchi T, Igari H, Hanaoka H, Yokote K, Tsuyuzaki K, Nakajima H, Kawakami E. Detecting time-evolving phenotypic components of adverse reactions against BNT162b2 SARS-CoV-2 vaccine via non-negative tensor factorization.iScience. 2022 Oct 21;25(10):105237. doi: 10.1016/j.isci.2022.105237.
後藤　義幸　腸内細菌の遺伝子操A69:D89いて一遺伝子レベルでの機能解析が可能となる　 Microbiome Science　2022年　1卷 2号 p43-45.
平原潔、小久保幸太、中山俊憲　CD4陽性T細胞と肺の線維化　医学のあゆみ　283(1):4-9 (2022).
Hashimoto Y, Eguchi A, Wei Y, Shinno-Hashimoto H, Fujita Y, Ishima T, Chang L, Mori C, Suzuki T, Hashimoto K. Antibiotic-induced microbiome depletion improves LPS-induced acute lung injury via gut-lung axis.　Life Sci. 2022 Oct 15;307:120885. doi: 10.1016/j.lfs.2022.120885.
Nishimura N, Yokota M, Kurihara S, Iwata A, Kageyama T, Ito T, Saku A, Maezawa Y, Hirose K, Nakajima H. Airway epithelial STAT3 inhibits allergic inflammation via upregulation of stearoyl-CoA desaturase 1. Allergol Int. 2022 Oct;71(4):520-527. doi: 10.1016/j.alit.2022.05.002.
Adachi M, Taniguchi K, Hori H, Mizutani T, Ishizaka A, Ishikawa K, Matano T, Opare D, Arhin D, Asiedu FB, Ampofo WK, Yeboah DM, Koram KA, Anang AK, Kiyono H. Strengthening surveillance in Ghana against public health emergencies of international concern. Trop Med Health. 2022 Oct 28;50(1):81. doi: 10.1186/s41182-022-00473-w.